Project information
- Category: Original Research
- Researchers:: Yeckley, M., Sabbagh, M., Santiago, M., Moriarty, S., Santiago, R., Patel, J., Peddibhotla, V., Perera, I., Rawlins II, F.
Abstract
Current literature demonstrates the highest prevalence of prostate cancer among black men in the United States. According to the American Cancer Society, in American men, prostate cancer is the second leading cause of cancer death following lung cancer, most commonly metastasizing to the bones and lymph nodes. Data indicates that black patients are disproportionately affected by prostate cancer, suffering from higher rates of aggressive and metastatic disease and higher mortality rates. Risk factors for prostate cancer, although some still debated, include diet, exercise, cigarette smoking and obesity. These potential risk factors within this population may be attributed to, but not limited to, minority populations disproportionately affected by food deserts, food swamps, and unemployment. Furthermore, research has demonstrated black patients are more likely to experience delayed treatment, underutilization of treatments, poor interactions with physicians and longer referral times when compared to other racial and ethnic groups. Beyond psychosocial factors, biologic factors such as genetics, have a potential role for utility in screening and treatments. The goal of this study is to review the 2020 Surveillance, Epidemiology and End Results (SEER) results and review literature to improve the current understanding of prostate cancer risk factors.
References
1. Key statistics for prostate cancer. (2024, January 19).
https://www.cancer.org/cancer/types/prostate-cancer/about/key-statistics.html
2. Rawla, P. (2019). Epidemiology of Prostate Cancer. World Journal of Oncology, 10(2),
63–89.
3. Fletcher, S. A., Marchese, M., Cole, A. P., Mahal, B. A., Friedlander, D. F.,
Krimphove, M., Kilbridge, K. L., Lipsitz, S. R., Nguyen, P. L., Choueiri, T. K., Kibel,
A. S., & Trinh, Q.-D. (2020). Geographic Distribution of Racial Differences in Prostate
Cancer Mortality. JAMA Network Open, 3(3), e201839.
4. Giaquinto, A. N., Miller, K. D., Tossas, K. Y., Winn, R. A., Jemal, A., & Siegel, R.
L. (2022). Cancer statistics for African American/Black People 2022. CA: A Cancer
Journal for Clinicians, 72(3), 202–229.
5. Carlo, M. I., Giri, V. N., Paller, C. J., Abida, W., Alumkal, J. J., Beer, T. M.,
Beltran, H., George, D. J., Heath, E. I., Higano, C. S., McKay, R. R., Morgans, A. K.,
Patnaik, A., Ryan, C. J., Schaeffer, E. M., Stadler, W. M., Taplin, M.-E., Kauff, N. D.,
Vinson, J., … Cheng, H. H. (2018). Evolving Intersection Between Inherited Cancer
Genetics and Therapeutic Clinical Trials in Prostate Cancer: A White Paper From the
Germline Genetics Working Group of the Prostate Cancer Clinical Trials Consortium. JCO
Precision Oncology, 2018. https://doi.org/10.1200/PO.18.00060
6. Johnson, J. R., Woods-Burnham, L., Hooker, S. E., Jr, Batai, K., & Kittles, R. A.
(2021). Genetic Contributions to Prostate Cancer Disparities in Men of West African
Descent. Frontiers in Oncology, 11, 770500.
7. Krimphove, M. J., Cole, A. P., Fletcher, S. A., Harmouch, S. S., Berg, S., Lipsitz,
S. R., Sun, M., Nabi, J., Nguyen, P. L., Hu, J. C., Kibel, A. S., Choueiri, T. K.,
Kluth, L. A., & Trinh, Q.-D. (2019). Evaluation of the contribution of demographics,
access to health care, treatment, and tumor characteristics to racial differences in
survival of advanced prostate cancer. Prostate Cancer and Prostatic Diseases, 22(1),
125–136.
8. Matsushita, M., Fujita, K., & Nonomura, N. (2020). Influence of Diet and Nutrition on
Prostate Cancer. International Journal of Molecular Sciences, 21(4).
https://doi.org/10.3390/ijms21041447
9. SEER*Explorer. (n.d.). Retrieved January 24, 2024, from
https://seer.cancer.gov/statistics-network/explorer/application.html?site=66&data_type=2&graph_type=2&compareBy=race&chk_race_6=6&chk_race_5=5&chk_race_4=4&chk_race_9=9&chk_race_2=2&hdn_sex=2&age_range=1&advopt_precision=1&advopt_show_ci=on&hdn_view=0&advopt_show_apc=on&advopt_display=2
10. Lawrence, W. R., McGee-Avila, J. K., Vo, J. B., Luo, Q., Chen, Y., Inoue-Choi, M.,
Berrington de González, A., Freedman, N. D., & Shiels, M. S. (2022). Trends in Cancer
Mortality Among Black Individuals in the US From 1999 to 2019. JAMA Oncology, 8(8),
1184–1189.
11. Wu, I., & Modlin, C. S. (2012). Disparities in prostate cancer in African American
men: what primary care physicians can do. Cleveland Clinic Journal of Medicine, 79(5),
313–320.
12. Parikh, R. B., Gallo, J. J., Wong, Y.-N., Robinson, K. W., Cashy, J. P., Narayan,
V., Jayadevappa, R., & Chhatre, S. (2021). Long-term depression incidence and associated
mortality among African American and White prostate cancer survivors. Cancer, 127(18),
3476–3485.
13. Dinh, K. T., Reznor, G., Muralidhar, V., Mahal, B. A., Nezolosky, M. D., Choueiri,
T. K., Hoffman, K. E., Hu, J. C., Sweeney, C. J., Trinh, Q.-D., & Nguyen, P. L. (2016).
Association of Androgen Deprivation Therapy With Depression in Localized Prostate
Cancer. Journal of Clinical Oncology: Official Journal of the American Society of
Clinical Oncology, 34(16), 1905–1912.
14. Lin, P.-H., Liu, J.-M., Hsu, R.-J., Chuang, H.-C., Chang, S.-W., Pang, S.-T., Chang,
Y.-H., Chuang, C.-K., & Lin, S.-K. (2018). Depression Negatively Impacts Survival of
Patients with Metastatic Prostate Cancer. International Journal of Environmental
Research and Public Health, 15(10). https://doi.org/10.3390/ijerph15102148
15. Campbell, L. C., Keefe, F. J., McKee, D. C., Edwards, C. L., Herman, S. H., Johnson,
L. E., Colvin, O. M., McBride, C. M., & Donattuci, C. F. (2004). Prostate cancer in
African Americans: relationship of patient and partner self-efficacy to quality of life.
Journal of Pain and Symptom Management, 28(5), 433–444.
16. Pietro, G. D., Chornokur, G., Kumar, N. B., Davis, C., & Park, J. Y. (2016). Racial
Differences in the Diagnosis and Treatment of Prostate Cancer. International
Neurourology Journal, 20(Suppl 2), S112–S119.
17. Lowder, D., Rizwan, K., McColl, C., Paparella, A., Ittmann, M., Mitsiades, N., &
Kaochar, S. (2022). Racial disparities in prostate cancer: A complex interplay between
socioeconomic inequities and genomics. Cancer Letters, 531, 71–82.
18. Press, D. J., Shariff-Marco, S., Lichtensztajn, D. Y., Lauderdale, D., Murphy, A.
B., Inamdar, P. P., DeRouen, M. C., Hamilton, A. S., Yang, J., Lin, K., Hedeker, D.,
Haiman, C. A., Cheng, I., & Gomez, S. L. (2022). Contributions of Social Factors to
Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men
with Prostate Cancer in California. Cancer Epidemiology, Biomarkers & Prevention: A
Publication of the American Association for Cancer Research, Cosponsored by the American
Society of Preventive Oncology, 31(2), 404–412.
19. Cooksey Stowers, K., Jiang, Q., Atoloye, A., Lucan, S., & Gans, K. (2020). Racial
Differences in Perceived Food Swamp and Food Desert Exposure and Disparities in
Self-Reported Dietary Habits. International Journal of Environmental Research and Public
Health, 17(19). https://doi.org/10.3390/ijerph17197143
20. Wang, Y., & Chen, X. (2011). How much of racial/ethnic disparities in dietary
intakes, exercise, and weight status can be explained by nutrition- and health-related
psychosocial factors and socioeconomic status among US adults? Journal of the American
Dietetic Association, 111(12), 1904–1911.
21. Ghosh-Dastidar, B., Cohen, D., Hunter, G., Zenk, S. N., Huang, C., Beckman, R., &
Dubowitz, T. (2014). Distance to store, food prices, and obesity in urban food deserts.
American Journal of Preventive Medicine, 47(5), 587–595.
22. Bancroft, E. K., Raghallaigh, H. N., Page, E. C., & Eeles, R. A. (2021). Updates in
Prostate Cancer Research and Screening in Men at Genetically Higher Risk. Current
Genetic Medicine Reports, 9(4), 47–58.
23. Castro, E., & Eeles, R. (2012). The role of BRCA1 and BRCA2 in prostate cancer.
Asian Journal of Andrology, 14(3), 409–414.
24. Adhyam, M., & Gupta, A. K. (2012). A Review on the Clinical Utility of PSA in Cancer
Prostate. Indian Journal of Surgical Oncology, 3(2), 120–129.
25. Shenoy, D., Packianathan, S., Chen, A. M., & Vijayakumar, S. (2016). Do
African-American men need separate prostate cancer screening guidelines? BMC Urology,
16(1), 19.
26. Powell, I. J., Vigneau, F. D., Bock, C. H., Ruterbusch, J., & Heilbrun, L. K.
(2014). Reducing prostate cancer racial disparity: evidence for aggressive early
prostate cancer PSA testing of African American men. Cancer Epidemiology, Biomarkers &
Prevention: A Publication of the American Association for Cancer Research, Cosponsored
by the American Society of Preventive Oncology, 23(8), 1505–1511.